Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741088 | 0.85 | HTR2B (0.39) | HTR2BCXCR3POLBKMT2AKDM4E | |
| SCHEMBL765151 | 0.84 | PTPN1 (0.41) | HTR2BCXCR3POLBKMT2AKDM4E | |
| SCHEMBL742573 | 0.77 | GRIN2B (0.49) | HTR2BPOLBKMT2AKDM4EMAPK1 | |
| SCHEMBL762632 | 0.76 | PTGS1 (0.53) | POLBKMT2AKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL762990 | 0.75 | KCNH2 (0.39) | POLBKMT2AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL742770 | 0.71 | HTR2B (0.50) | HTR2BPOLBKDM4ESMN1; SMN2MAPT | |
| SCHEMBL742005 | 0.67 | GRIN2B (0.52) | HTR2BPOLBKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL741958 | 0.67 | KDM4E (0.57) | POLBKDM4EMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20622607 | 0.67 | HTR2B (0.67) | HTR2BPOLBKDM4E | |
| SCHEMBL12030470 | 0.66 | TRPC3 (0.49) | HTR2BKMT2AKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |