Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762987 | 0.84 | HTR2B (0.42) | CXCR3POLBMAPTHTR2BKDM4E | |
| SCHEMBL762864 | 0.82 | MAPK1 (0.45) | CTSBCTSSCTSKPOLBMAPT | |
| SCHEMBL762586 | 0.82 | CYP1A2 (0.42) | CTSBCTSSCTSKPOLBKDM4E | |
| SCHEMBL741088 | 0.81 | HTR2B (0.39) | CXCR3POLBHTR2BKDM4EKMT2A | |
| SCHEMBL762654 | 0.81 | MAPK1 (0.43) | CTSBCTSSCTSKPOLBMAPT | |
| SCHEMBL763211 | 0.81 | CYP1A2 (0.41) | CTSBCTSSCTSKPOLBKDM4E | |
| SCHEMBL763789 | 0.80 | CTSB (0.37) | CTSBCTSSCTSKPOLBMAPT | |
| SCHEMBL763468 | 0.80 | GRIN2B (0.49) | PTPN1POLBMAPTITGB3ITGAV | |
| SCHEMBL763367 | 0.80 | GRIN2B (0.49) | PTPN1POLBMAPTITGB3ITGAV | |
| SCHEMBL762470 | 0.80 | GRIN2B (0.49) | PTPN1POLBMAPTITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |