Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762987 | 0.85 | HTR2B (0.42) | HTR2BCXCR3MAPK1POLBKDM4E | |
| SCHEMBL739128 | 0.82 | MAPK1 (0.46) | MAPK1POLBKDM4EKMT2ACYP1A2 | |
| SCHEMBL765151 | 0.81 | PTPN1 (0.41) | HTR2BCXCR3MAPK1POLBKDM4E | |
| SCHEMBL741506 | 0.80 | MAPK1 (0.44) | MAPK1POLBKDM4EKMT2ACYP1A2 | |
| SCHEMBL741405 | 0.80 | CYP1A2 (0.42) | MAPK1POLBKDM4EKMT2ACYP1A2 | |
| SCHEMBL740770 | 0.80 | HTR2B (0.49) | HTR2BMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL741843 | 0.79 | PTGS1 (0.51) | MAPK1POLBKDM4EKMT2ACYP1A2 | |
| SCHEMBL740023 | 0.79 | GRIN2B (0.50) | HTR2BMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL740304 | 0.79 | GRIN2B (0.50) | HTR2BMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL739281 | 0.79 | POLB (0.46) | HTR2BMAPK1POLBKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |