Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL366323 | 0.89 | TGFBR1 (0.46) | TGFBR1TP53CYP2C9CYP2C19KDM4E | |
| SCHEMBL31130 | 0.87 | L3MBTL1 (0.44) | TGFBR1PTGS1KCNH2L3MBTL1KDM4E | |
| Methacrylic Acid SCHEMBL4419898 | 0.85 | L3MBTL1 (0.41) | TGFBR1PTGS1KCNH2L3MBTL1KDM4E | |
| Lactic Acid SCHEMBL8862045 | 0.85 | KDM4E (0.47) | TGFBR1TP53KDM4EKMT2AMEN1 | |
| Lactic Acid SCHEMBL544712 | 0.82 | TGFBR1 (0.48) | TGFBR1TP53CYP2C19KDM4EKMT2A | |
| SCHEMBL10448873 | 0.81 | L3MBTL1 (0.36) | TGFBR1PTGS1KCNH2L3MBTL1KDM4E | |
| SCHEMBL138809 | 0.81 | KDM4E (0.44) | TGFBR1L3MBTL1KDM4EKMT2AMEN1 | |
| SCHEMBL8219357 | 0.80 | KDM4E (0.48) | L3MBTL1KDM4EMAPK1HIF1ATDP1 | |
| SCHEMBL18139435 | 0.80 | KDM4E (0.48) | L3MBTL1KDM4EMAPK1HIF1ATDP1 | |
| SCHEMBL8218361 | 0.80 | KDM4E (0.48) | L3MBTL1KDM4EMAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214361-A1 | TEMPERATURE SENSITIVE POLYMERS | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2002-06-19 | — | — | EP | claimed |
| WO-2001009198-A1 | TEMPERATURE SENSITIVE POLYMERS | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2001-02-08 | — | — | WO | claimed |
| CN-108367100-B | Photoactivated preparation of hydrogels | 奥塔哥创新有限公司 | 2022-03-22 | — | — | CN | disclosed |