Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135750 | 0.82 | RXFP1 (0.57) | KDM4EALDH1A1SMN1; SMN2RXFP1HTR7 | |
| SCHEMBL6669660 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B | |
| SCHEMBL3453978 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B | |
| Hydrochloric Acid SCHEMBL15048947 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B | |
| SCHEMBL4212045 | 0.80 | LMNA (0.63) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B | |
| SCHEMBL8341399 | 0.80 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2RXFP1HTR7 | |
| SCHEMBL10446494 | 0.80 | HCRTR1 (0.57) | KDM4EALDH1A1RXFP1LMNA | |
| SCHEMBL7956961 | 0.79 | ALDH1A1 (0.58) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B | |
| SCHEMBL11475373 | 0.78 | HTT (0.54) | KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6671023 | 0.78 | HRH1 (0.54) | KDM4EALDH1A1SMN1; SMN2HTR7HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350892-B1 | ENZYME INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-26 | — | — | US | disclosed |
| EP-1140791-A4 | SELECTIVE CPLA 2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140791-A2 | SELECTIVE CPLA 2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-1999015129-A2 | SELECTIVE cPLA2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |