Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 14/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733458 | 0.84 | HPGD (0.58) | LTB4RKDM4EALDH1A1 | |
| SCHEMBL28493223 | 0.83 | ALDH1A1 (0.70) | LTB4RPLA2G2AADORA1ADORA3KDM4E | |
| SCHEMBL28490522 | 0.81 | TSHR (0.57) | PLA2G2AADORA1ADORA3KDM4EALDH1A1 | |
| SCHEMBL762872 | 0.78 | ALDH1A1 (0.49) | KDM4EALDH1A1ALPL | |
| SCHEMBL28496947 | 0.76 | ALDH1A1 (0.52) | PLA2G2AADORA1ADORA3KDM4EALDH1A1 | |
| SCHEMBL19330120 | 0.76 | KDM4E (0.72) | PLA2G2AADORA1ADORA3KDM4EALDH1A1 | |
| SCHEMBL762838 | 0.75 | MAPT (0.55) | PLA2G2AALPL | |
| SCHEMBL7110386 | 0.74 | LTB4R (0.68) | LTB4R | |
| SCHEMBL732748 | 0.74 | KDM4E (0.51) | PLA2G2AADORA1ADORA3KDM4EALDH1A1 | |
| SCHEMBL731626 | 0.74 | SDHB (0.47) | LTB4RPLA2G2AADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112048734-B | Regioselective electrochemical synthesis method of nitrogen-containing aromatic heterocyclic carboxylic ester | 四川大学 | 2022-06-10 | — | — | CN | disclosed |
| CN-112048734-A | Regioselective electrochemical synthesis method of nitrogen-containing aromatic heterocyclic carboxylic acid | 四川大学 | 2020-12-08 | — | — | CN | disclosed |
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | LTB4R 1240/4885PLA2G2A 4546/4885ADORA1 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.