Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 1.00 |
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.74 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL29938690 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3031563 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL8218174 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL10329428 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL13696342 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL16922140 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL21077535 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL14371354 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777477-B1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 2002-11-13 | — | — | EP | claimed |
| CN-115057865-A | Preparation method of codeine phosphate hemihydrate | 国药集团工业有限公司 | 2022-09-16 | — | — | CN | disclosed |