Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 1.00 |
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.74 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL29938690 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7632902 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL8218174 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL10329428 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL13696342 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL16922140 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL21077535 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL14371354 | 0.99 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230001128-A1 | AEROSOLIZATION SYSTEMS, METHODS, AND APPARATUSES | SHUSTER GARY STEPHEN (CA) | 2023-01-05 | — | — | US | disclosed |
| US-20150133664-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | UNIV TEXAS (US) | 2015-05-14 | — | — | US | disclosed |
| WO-2013184902-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-12-12 | — | — | WO | disclosed |
| US-8450365-B2 | Efficient synthesis of galanthamine | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-28 | — | — | US | disclosed |
| US-8362283-B2 | Cross-conjugated 2,5-cyclohexadienone and related synthesis methods | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-01-29 | — | — | US | disclosed |
| CN-102813654-A | Matrix for sustained, invariant and independent release of active compounds | EURO CELTIQUE SA | 2012-12-12 | — | — | CN | disclosed |
| US-8293927-B2 | Efficient synthesis of morphine and codeine | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-10-23 | — | — | US | disclosed |
| CN-1646102-B | Pharmaceutical preparation containing oxycodone and naloxone | EURO CELTIQUE SA | 2012-08-15 | — | — | CN | disclosed |
| CN-102387704-A | Agonists and antagonists of the S1P5 receptor, and methods of uses thereof | ABBOTT LAB | 2012-03-21 | — | — | CN | disclosed |
| EP-2395835-A1 | AGONISTS AND ANTAGONISTS OF THE SIP5 RECEPTOR, AND METHODS OF USES THEREOF | Abbott Laboratories (US) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010132570-A1 | SYNTHESIS OF MORPHINE AND RELATED DERIVATIVES | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292475-A1 | Efficient Synthesis Of Morphine And Codeine | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM | 2010-11-18 | — | — | US | disclosed |
| US-20100228032-A1 | Process for Making Apomorphine and Apocodeine | MALLINCKRODT INC. | 2010-09-09 | — | — | US | disclosed |
| US-20100216998-A1 | Facile \"One Pot' Process for Apomorphine From Codeine | MALLINCKRODT INC. (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
| WO-2010093704-A1 | AGONISTS AND ANTAGONISTS OF THE S1P5 RECEPTOR, AND METHODS OF USES THEREOF | ABBOTT LABORATORIES (US) | 2010-08-19 | — | — | WO | disclosed |
| EP-2190818-A1 | FACILE 'ONE POT' PROCESS FOR APOMORPHINE FROM CODEINE | Mallinckrodt Inc. (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009038958-A1 | FACILE 'ONE POT' PROCESS FOR APOMORPHINE FROM CODEINE | MALLINCKRODT INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| EP-2007730-A1 | PROCESS FOR MAKING APOMORPHINE AND APOCODEINE | Mallinckrodt, Inc. (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007126659-A1 | PROCESS FOR MAKING APOMORPHINE AND APOCODEINE | MALLINCKRODT INC. (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228032-A1 | Process for Making Apomorphine and Apocodeine | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
| US-20100216998-A1 | Facile \"One Pot' Process for Apomorphine From Codeine | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OPRD1 3/4885OPRK1 2/4885 |
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | S1PR5, LPAR5, S1PR1 | OPRM1 209/4885OPRD1 215/4885OPRK1 72/4885 |
| US-20100292475-A1 | Efficient Synthesis Of Morphine And Codeine | OPRK1, OPRM1, OPRL1 | OPRM1 2/4885OPRD1 5/4885OPRK1 1/4885 |
| US-20150133664-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.