Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL207126 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL11218475 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL29270383 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL29270380 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL11588624 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL25387939 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL11292367 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL904376 | 0.89 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL27812553 | 0.89 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1CA2CA4 | |
| Styrene SCHEMBL28084426 | 0.89 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975215-B1 | PLANT PROTECTION AGENTS | STEFES AGRO GMBH (DE) | 2002-08-28 | — | — | EP | claimed |
| EP-0975215-A1 | PLANT PROTECTION AGENTS | Stefes Agro GmbH (DE) | 2000-02-02 | — | — | EP | claimed |
| WO-1998046075-A1 | PLANT PROTECTION AGENTS | STEFES AGRO GMBH (DE) | 1998-10-22 | — | — | WO | claimed |