Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7639980 | 0.95 | GAA (0.41) | KIF11ALDH1A1CES2CES1TSHR | |
| SCHEMBL7644315 | 0.81 | GRM2 (0.44) | TDP1MAPTCES1NPC1RAB9A | |
| SCHEMBL3927998 | 0.75 | ALDH1A1 (0.52) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL8046600 | 0.75 | GRM2 (0.41) | L3MBTL1MAPTOPRM1NAAARAB9A | |
| SCHEMBL27572321 | 0.74 | OPRM1 (0.49) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL2517312 | 0.74 | KIF11 (0.48) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL6478875 | 0.74 | KIF11 (0.48) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL28003885 | 0.74 | KIF11 (0.48) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL8059153 | 0.74 | GRM2 (0.40) | L3MBTL1MAPTOPRM1NAAARAB9A | |
| SCHEMBL11795626 | 0.73 | KIF11 (0.48) | KIF11L3MBTL1KMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |