Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.80 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7186247 | 0.94 | TOP2A (0.75) | TOP2ATERTMAOAMEN1THRB | |
| Ascididemin SCHEMBL6841381 | 0.89 | TOP2A (1.00) | TOP2ATERTMAOAMEN1THRB | |
| Ascididemin SCHEMBL30547678 | 0.89 | TOP2A (1.00) | TOP2ATERTMAOAMEN1THRB | |
| Benzosampangine SCHEMBL29601408 | 0.88 | TOP2A (0.79) | TOP2ATERTMAOAPTPRCCTSL | |
| Benzosampangine SCHEMBL20259217 | 0.88 | TOP2A (0.79) | TOP2ATERTMAOAPTPRCCTSL | |
| SCHEMBL6845499 | 0.84 | TOP2A (0.57) | TOP2ATERTMAOAMEN1THRB | |
| SCHEMBL6845596 | 0.83 | TOP2A (0.56) | TOP2ATERTMAOAMEN1THRB | |
| SCHEMBL20259026 | 0.80 | TOP2A (0.66) | TOP2ATERTMAOACDC25BALDH1A1 | |
| SCHEMBL16072069 | 0.79 | TOP2A (0.51) | TOP2AMAOAMEN1THRBBLM | |
| SCHEMBL7184746 | 0.79 | TOP2A (0.57) | TOP2ATERTMAOAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | claimed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | claimed |