Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442154 | 0.86 | CYP2C9 (0.43) | CYP2C9CYP2C19 | |
| SCHEMBL7636852 | 0.80 | FPR2 (0.34) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7455118 | 0.79 | ELANE (0.40) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL7402496 | 0.77 | ELANE (0.44) | ALDH1A1OPRM1THRBCYP2C9CYP2C19 | |
| SCHEMBL17667391 | 0.69 | ADORA3 (0.41) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7400071 | 0.69 | GAA (0.47) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL24491102 | 0.68 | ADORA3 (0.40) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7395476 | 0.68 | CASP2 (0.46) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7400883 | 0.68 | MAPT (0.41) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7405306 | 0.68 | MAPT (0.41) | NPC1LMNAMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468977-B1 | COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS | APOTEX INC. (CA) | 2002-10-22 | — | — | US | disclosed |
| US-6162791-A | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes | APOTEX INC. (CA) | 2000-12-19 | — | — | US | disclosed |