Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 3/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874217 | 0.97 | CHRNB2 (0.49) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6881376 | 0.90 | CHRNB2 (0.47) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6882082 | 0.87 | CHRNB2 (0.44) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6882503 | 0.86 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6880900 | 0.86 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6885081 | 0.84 | CHRNB2 (0.52) | CHRNB2CHRNA7CHRNA4CCNE1CDK2 | |
| SCHEMBL6881291 | 0.84 | CHRNB2 (0.42) | CHRNB2CHRNA7CHRNA4LOXLOXL2 | |
| SCHEMBL6872621 | 0.83 | SCN9A (0.43) | CHRNB2CHRNA7CHRNA4LMNARAB9A | |
| SCHEMBL6881115 | 0.83 | P2RX3 (0.43) | CHRNB2CHRNA7CHRNA4LOXLOXL2 | |
| SCHEMBL6882895 | 0.83 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052389-A1 | Treating a disease or condition in a mammal, wherein the alpha 7 nicotinic-acetylcholine receptor is implicated | PHARMACIA & UPJOHN COMPANY | 2002-05-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052389-A1 | Treating a disease or condition in a mammal, wherein the alpha 7 nicotinic-acetylcholine receptor is implicated | CHRNA7, CHRNA1, CHRNB1 | CHRNB2 14/4885CHRNA7 1/4885CHRNA4 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.