SCHEMBL7638345

SCHEMBL7638345

Cc1cn([C@H]2C[C@H](O)[C@@H](COC(CN)C(=O)CCCCCN)O2)c(=O)nc1N

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 5/20 0.40
DNMT3B Q9UBC3 1/20 0.40
ADRB1 P08588 1/20 0.38
POLB P06746 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776342 0.85 POLB (0.53) DNMT1ADRB1POLB
SCHEMBL8028517 0.85 P2RY6 (0.36) DNMT1
SCHEMBL26757521 0.78 DNMT1 (0.48) DNMT1DNMT3BADRB1POLB
SCHEMBL26757231 0.78 DNMT1 (0.48) DNMT1DNMT3BADRB1POLB
SCHEMBL6397616 0.75 DNMT1 (0.46) DNMT1DNMT3BADRB1POLB
SCHEMBL18180945 0.75 POLB (0.55) POLB
SCHEMBL502418 0.75 POLB (0.55) POLB
SCHEMBL9900767 0.75 POLB (0.55) POLB
SCHEMBL7644133 0.75 DNMT1 (0.43) DNMT1DNMT3BADRB1
SCHEMBL23547948 0.75 DNMT1 (0.51) DNMT1DNMT3BADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6465175-B2 REDUCING BACKGROUND SIGNALS IN NUCLEIC ACID HYBRIDIZATION ASSAYS BY USING AN OLIGONUCLEOTIDE LABELLED WITH A QUENCHABLE DIPYRROLOMETHENEBORON DIFLUORIDE DYE BAYER CORPORATION 2002-10-15 US disclosed
US-20010009760-A1 OLIGONUCLEOTIDE PROBES BEARING QUENCHABLE FLUORESCENT LABELS, AND METHODS OF USE THEREOF CHIRON DIAGNOSTICS CORPORATION 2001-07-26 US disclosed
EP-1009852-A2 OLIGONUCLEOTIDE PROBES BEARING QUENCHABLE FLUORESCENT LABELS, AND METHODS OF USE THEREOF Bayer Corporation (US) 2000-06-21 EP disclosed
EP-0510085-B1 DNA-DEPENDENT RNA POLYMERASE TRANSCRIPTS AS REPORTER MOLECULES FOR SIGNAL AMPLIFICATION IN NUCLEIC ACID HYBRIDIZATION ASSAYS CHIRON DIAGNOSTICS CORP (US) 1999-09-08 EP disclosed
WO-1999011813-A2 OLIGONUCLEOTIDE PROBES BEARING QUENCHABLE FLUORESCENT LABELS, AND METHODS OF USE THEREOF BAYER CORPORATION (US) 1999-03-11 WO disclosed
US-5629153-A DIAGNOSIS CHIRON CORPORATION (US) 1997-05-13 US disclosed