SCHEMBL7638465

SCHEMBL7638465

FC(Cl)(Cl)C(F)(F)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.60
ALDH1A1 P00352 2/20 0.52
CYP1A2 P05177 1/20 0.42
PTPN1 P18031 2/20 0.41
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA5A P35218 1/20 0.39
CA9 Q16790 1/20 0.39
KCNN4 O15554 4/20 0.39
KIF11 P52732 1/20 0.39
MAPK1 P28482 1/20 0.35
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
PGK1 P00558 1/20 0.33
PGK2 P07205 1/20 0.33
PTPN5 P54829 1/20 0.32
TRPV6 Q9H1D0 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
ALOX15 P16050 1/20 0.32
CES1 P23141 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10601694 0.83 TSHR (0.60) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL11691261 0.83 TSHR (0.60) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL9723026 0.82 ALDH1A1 (0.65) TSHRALDH1A1CYP1A2PTPN1CA1
Trifluoromethylbenzene SCHEMBL8966589 0.78 TSHR (0.78) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL11693413 0.78 TSHR (0.52) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL5720508 0.77 TSHR (0.58) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL4219815 0.77 TSHR (0.58) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL21082645 0.77 TSHR (0.58) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL17288747 0.77 TSHR (0.58) TSHRALDH1A1CYP1A2PTPN1CA1
SCHEMBL146900 0.77 TSHR (0.58) TSHRALDH1A1CYP1A2PTPN1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350925-B1 HALOETHYLATION OF AROMATIC COMPOUNDS 3M INNOVATIVE PROPERTIES COMPANY 2002-02-26 US disclosed
US-5364917-A Perfluorocyclobutane ring-containing polymers THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
EP-0428708-B1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS DOW CHEMICAL CO (US) 1994-10-05 EP disclosed
US-5159037-A Crosslinking THE DOW CHEMICAL COMPANY (US) 1992-10-27 US disclosed
US-5159038-A Flexibility, tensile strength DOW CHEMICAL COMPANY (US) 1992-10-27 US disclosed
US-5066746-A Dielectric Fluids, Lubricants And Plastics THE DOW CHEMICAL COMPANY (US) 1991-11-19 US disclosed
US-5037917-A Polymerizing Monomers Containing At Least Two Perfluorovinyl Groups, Then Heating To Form Perfluorocyclobutane Rings THE DOW CHEMICAL COMPANY (US) 1991-08-06 US disclosed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed