Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 9/20 | 0.47 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144891 | 0.86 | CXCR3 (0.62) | CXCR3 | |
| SCHEMBL5156390 | 0.77 | CXCR3 (0.46) | PIK3CDPIK3CGCXCR3 | |
| SCHEMBL14621242 | 0.74 | CXCR3 (0.79) | CXCR3 | |
| SCHEMBL9067778 | 0.74 | CXCR3 (0.59) | CXCR3 | |
| SCHEMBL15812952 | 0.72 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL20061285 | 0.72 | PIK3CG (0.57) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL16677349 | 0.71 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL16677764 | 0.71 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL16677254 | 0.71 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL15870097 | 0.71 | PIK3CG (0.56) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216232-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR MODULATING CXCR3 FUNCTION | Chemocentryx, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001016114-A2 | HETEROCYCLIC COMPOUNDS AND METHODS FOR MODULATING CXCR3 FUNCTION | CHEMOCENTRYX, INC. (US) | 2001-03-08 | — | — | WO | disclosed |