Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 11/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095480 | 0.79 | MMP12 (0.44) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8201930 | 0.79 | NR3C2 (0.42) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8487320 | 0.74 | NR3C2 (0.40) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8182884 | 0.73 | NR3C2 (0.51) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3489518 | 0.72 | NR3C2 (0.47) | NR3C2MMP12ALDH1A1PARP1GRM5 | |
| SCHEMBL20125045 | 0.72 | NR3C2 (0.44) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL15053068 | 0.71 | DRD2 (0.43) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14080066 | 0.70 | MMP12 (0.49) | NR3C2MMP12KMT2ASMN1; SMN2PARP1 | |
| SCHEMBL8182873 | 0.70 | NR3C2 (0.42) | NR3C2MMP12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4100343 | 0.68 | DRD2 (0.40) | NR3C2MMP12ALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625982-B1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | UPJOHN CO (US) | 2002-06-12 | — | — | EP | disclosed |
| US-5610158-A | ANXIOLYTIC AGENTS, SEDATIVES | THE UPJOHN COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0625982-A1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016082-A1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | THE UPJOHN COMPANY (US) | 1993-08-19 | — | — | WO | disclosed |