Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641392 | 1.00 | MEN1 (0.55) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL11692429 | 0.82 | MEN1 (0.73) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL11692422 | 0.82 | MEN1 (0.73) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL11911194 | 0.80 | ENPP2 (0.49) | MEN1KMT2ACA12CA2GLO1 | |
| SCHEMBL29267948 | 0.78 | MEN1 (0.67) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL29267949 | 0.78 | MEN1 (0.67) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL7643840 | 0.77 | KDM4E (0.53) | MEN1NPC1KMT2AENPP2 | |
| SCHEMBL7643843 | 0.77 | KDM4E (0.53) | MEN1NPC1KMT2AENPP2 | |
| SCHEMBL4850919 | 0.77 | KMT2A (0.61) | MEN1NPC1KMT2ACA12CA2 | |
| SCHEMBL670458 | 0.74 | HTR3E (0.43) | MEN1KMT2AENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448238-B1 | BORONIC ACIDS USED WITH BETA-LACTAM ANTIBIOTICS, SUCH AS AMOXICILLIN OR CEFTAZIDIME, TO TREAT BETA-LACTAM ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS | NORTHWESTERN UNIVERSITY | 2002-09-10 | — | — | US | claimed |
| US-6448238-B1 | BORONIC ACIDS USED WITH BETA-LACTAM ANTIBIOTICS, SUCH AS AMOXICILLIN OR CEFTAZIDIME, TO TREAT BETA-LACTAM ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS | NORTHWESTERN UNIVERSITY | 2002-09-10 | — | — | US | disclosed |
| US-6184363-B1 | Inhibitors of β-lactamases and uses therefor | NORTHWESTERN UNIVERSITY | 2001-02-06 | — | — | US | disclosed |