Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 15/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764884 | 0.88 | ADRB2 (0.55) | ADRB2ADRB1TAAR1 | |
| SCHEMBL13392152 | 0.87 | ADRB2 (0.53) | ADRB2ADRB1 | |
| SCHEMBL29818847 | 0.79 | ADRB2 (0.45) | ADRB2ADRB1TAAR1 | |
| SCHEMBL764163 | 0.78 | ADRB2 (0.51) | ADRB2ADRB1 | |
| SCHEMBL765334 | 0.78 | ADRB2 (0.51) | ADRB2ADRB1 | |
| SCHEMBL2361312 | 0.77 | ADRB2 (0.56) | ADRB2ADRB1 | |
| SCHEMBL2331246 | 0.77 | ADRB2 (0.56) | ADRB2ADRB1 | |
| SCHEMBL2328945 | 0.77 | ADRB2 (0.56) | ADRB2ADRB1 | |
| SCHEMBL9038190 | 0.76 | L3MBTL1 (0.53) | TAAR1 | |
| SCHEMBL14047090 | 0.76 | TAAR1 (0.45) | ADRB2ADRB1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054429-B1 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS | TRANZYME PHARMA INC (CA) | 2013-11-06 | — | — | EP | disclosed |
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2008033328-A2 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS | TRANZYME PHARMA, INC. (US) | 2008-03-20 | — | — | WO | disclosed |