Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 13/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765334 | 0.82 | ADRB2 (0.51) | ADRB2ADRB1KDM4ELMNACYP1A2 | |
| SCHEMBL764884 | 0.80 | ADRB2 (0.55) | ADRB2ADRB1LMNA | |
| SCHEMBL2361312 | 0.78 | ADRB2 (0.56) | ADRB2ADRB1KDM4ELMNACYP1A2 | |
| SCHEMBL764150 | 0.78 | ADRB2 (0.52) | ADRB2ADRB1 | |
| SCHEMBL2331246 | 0.78 | ADRB2 (0.56) | ADRB2ADRB1KDM4ELMNACYP1A2 | |
| SCHEMBL2328945 | 0.78 | ADRB2 (0.56) | ADRB2ADRB1KDM4ELMNACYP1A2 | |
| SCHEMBL6843990 | 0.75 | ADRB2 (0.66) | ADRB2ADRB1 | |
| SCHEMBL29818847 | 0.75 | ADRB2 (0.45) | ADRB2ADRB1 | |
| SCHEMBL11879638 | 0.74 | ADRB2 (0.58) | ADRB2ADRB1ALOX15 | |
| SCHEMBL9038190 | 0.72 | L3MBTL1 (0.53) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |