SCHEMBL7643085

SCHEMBL7643085

CCN(CCC(=O)OC)c1ccc(C=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.59
ALDH3A1 P30838 1/20 0.59
ALDH1A3 P47895 1/20 0.59
MAPT P10636 6/20 0.46
KDM4E B2RXH2 6/20 0.43
GAA P10253 4/20 0.43
GFER P55789 2/20 0.43
HPGD P15428 2/20 0.43
GLA P06280 1/20 0.43
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
KMT2A Q03164 5/20 0.41
CYP2A6 P11509 1/20 0.41
CYP2A13 Q16696 1/20 0.41
FGFR1 P11362 1/20 0.40
POLB P06746 3/20 0.40
ESRRG P62508 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MEN1 O00255 4/20 0.40
MCL1 Q07820 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11693529 0.83 CYP2A6 (0.46) ALDH1A1ALDH3A1ALDH1A3MAPTKMT2A
SCHEMBL16863794 0.83 ALDH1A1 (0.55) ALDH1A1MAPTGFERHPGDRAB9A
SCHEMBL7038319 0.83 MEN1 (0.49) ALDH1A1MAPTKDM4EGAAGFER
SCHEMBL11315216 0.80 MAPT (0.44) ALDH1A1MAPTHPGDRAB9ANPC1
SCHEMBL10942535 0.80 ALDH1A1 (0.83) ALDH1A1ALDH3A1ALDH1A3MAPTKDM4E
SCHEMBL7598406 0.78 ALDH1A1 (0.56) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL10938401 0.78 ALDH1A1 (0.67) ALDH1A1ALDH3A1ALDH1A3MAPTKDM4E
SCHEMBL11695333 0.77 ALDH1A1 (0.49) ALDH1A1ALDH3A1ALDH1A3MAPTKDM4E
SCHEMBL3190534 0.77 ALDH1A1 (0.71) ALDH1A1ALDH3A1ALDH1A3MAPTKDM4E
SCHEMBL6129323 0.77 ALDH1A1 (0.61) ALDH1A1ALDH3A1ALDH1A3MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6458966-B1 Dye intermediate and method NYCOMED AMERSHAM PLC (GB) 2002-10-01 US disclosed
EP-1002020-A1 DYE INTERMEDIATE AND METHOD TO MANUFACTURE DYES Nycomed Amersham plc (GB) 2000-05-24 EP disclosed
WO-1999007793-A1 DYE INTERMEDIATE AND METHOD TO MANUFACTURE DYES NYCOMED AMERSHAM PLC (GB) 1999-02-18 WO disclosed