Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207656 | 0.85 | HDAC4 (0.37) | CES2CES1 | |
| SCHEMBL10331380 | 0.85 | NR3C1 (0.37) | NR3C1CYP2C19PGRARCES2 | |
| SCHEMBL2896278 | 0.78 | NR3C1 (0.47) | NR3C1PGRARCES2CES1 | |
| SCHEMBL14207511 | 0.76 | NR3C1 (0.68) | NR3C1PGRAR | |
| SCHEMBL14207676 | 0.72 | HDAC4 (0.38) | CYP2C19CES2CES1CYP2D6LMNA | |
| SCHEMBL12592391 | 0.72 | MEN1 (0.47) | NR3C1PGRARCYP1A2LMNA | |
| SCHEMBL10331384 | 0.72 | HDAC4 (0.40) | CYP2C19CES2CES1CYP1A2LMNA | |
| SCHEMBL754423 | 0.72 | HDAC4 (0.40) | CYP2C19CES2CES1CYP1A2LMNA | |
| SCHEMBL10197988 | 0.70 | GABBR2 (0.42) | CYP2C19CES2CES1LMNA | |
| SCHEMBL2900773 | 0.69 | CNR2 (0.42) | NR3C1CYP2C19PGRARL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078015-B1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1 AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |