Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.48 |
| ▸ | ADK | P55263 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PYGM | P11217 | 3/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.43 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.43 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.43 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.43 |
| ▸ | TK2 | O00142 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740288 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL12154731 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL6727042 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL16198949 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL1737182 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL12150656 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL6729944 | 0.89 | PNP (0.54) | PAX8HIF1ADOT1LADKHPGD | |
| SCHEMBL31093987 | 0.82 | PAX8 (0.55) | PAX8HIF1ADOT1LADKALDH1A1 | |
| SCHEMBL1738360 | 0.78 | ADK (0.51) | PAX8HIF1ADOT1LADKALDH1A1 | |
| SCHEMBL1738396 | 0.78 | ADK (0.51) | PAX8HIF1ADOT1LADKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020147160-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | MERCK SHARP & DOHME LLC | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147160-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | NSUN2, NSUN3, POLRMT | PAX8 4785/4885HIF1A 3559/4885DOT1L 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.