SCHEMBL7645124

SCHEMBL7645124

COc1ccc(CCl)cc1C(=O)Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.47
MRGPRX4 Q96LA9 1/20 0.46
LMNA P02545 4/20 0.43
HPGD P15428 2/20 0.43
ALDH1A1 P00352 3/20 0.42
LDHA P00338 1/20 0.42
GAA P10253 1/20 0.42
CTSD P07339 1/20 0.41
DNMT3A Q9Y6K1 1/20 0.41
CA2 P00918 3/20 0.40
HTT P42858 3/20 0.40
CA1 P00915 2/20 0.40
CA9 Q16790 2/20 0.40
MAPT P10636 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CA12 O43570 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MITF O75030 1/20 0.40
MEN1 O00255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31252078 1.00 TTR (0.47) TTRMRGPRX4LMNAHPGDALDH1A1
SCHEMBL29196244 0.86 DRD2 (0.47) MRGPRX4LMNAHPGDALDH1A1LDHA
SCHEMBL9295122 0.86 TTR (0.47) TTRLMNAALDH1A1LDHAGAA
SCHEMBL31252031 0.86 MRGPRX4 (0.59) TTRMRGPRX4HPGDALDH1A1LDHA
SCHEMBL5453077 0.86 MRGPRX4 (0.59) TTRMRGPRX4HPGDALDH1A1LDHA
SCHEMBL31371151 0.85 HPGD (0.58) TTRMRGPRX4LMNAHPGDALDH1A1
SCHEMBL4159034 0.85 HPGD (0.58) TTRMRGPRX4LMNAHPGDALDH1A1
SCHEMBL31252170 0.85 LMNA (0.47) TTRMRGPRX4LMNAHPGDALDH1A1
SCHEMBL3293080 0.83 CFD (0.58) LMNAHPGDALDH1A1GAAHTT
SCHEMBL29196268 0.83 DRD2 (0.49) MRGPRX4LMNAALDH1A1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4486453-A1 BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS F. Hoffmann-La Roche AG (CH) 2025-01-08 EP disclosed
WO-2023166103-A1 BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS F. HOFFMANN-LA ROCHE AG (CH) 2023-09-07 WO disclosed
EP-0563345-B1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB INC (US) 2002-07-03 EP disclosed
US-5569659-A ANTIPSYCHOTIC AGENT MCNEILAB, INC. (US) 1996-10-29 US disclosed
EP-0563345-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-10-06 EP disclosed
EP-0562049-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-09-29 EP disclosed
WO-1993004682-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-03-18 WO disclosed
WO-1993004684-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-03-18 WO disclosed