Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8238907 | 0.85 | PKM (0.58) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL2070195 | 0.85 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL22700779 | 0.83 | RAB9A (0.50) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL5623097 | 0.83 | NPC1 (0.68) | SMN1; SMN2ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL3007602 | 0.82 | CSNK2A2 (0.60) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL13073361 | 0.82 | RAB9A (0.56) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL27701440 | 0.82 | RAB9A (0.73) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL854996 | 0.81 | RAB9A (0.61) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL842249 | 0.81 | NPC1 (0.48) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL3009762 | 0.81 | BCHE (0.68) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431369-A2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC Therapeutics, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |