Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.81 |
| ▸ | GFER | P55789 | 1/20 | 0.79 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603564 | 1.00 | ALDH1A1 (0.81) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| Hydrochloric Acid SCHEMBL10606849 | 0.98 | ALDH1A1 (0.82) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| SCHEMBL2834503 | 0.95 | ALDH1A1 (0.79) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| SCHEMBL5182996 | 0.93 | ALDH1A1 (0.76) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| SCHEMBL8525343 | 0.93 | ALDH1A1 (0.70) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| Fumaric Acid SCHEMBL10619017 | 0.93 | ALDH1A1 (0.70) | ALDH1A1KMT2AGFERDRD2HTR1A | |
| SCHEMBL10107784 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERHTR1AMAPT | |
| SCHEMBL5356971 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERHTR1AMAPT | |
| Hydrochloric Acid SCHEMBL29354698 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERMAPTEGFR | |
| Hydrochloric Acid SCHEMBL10675086 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERMAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157762-B1 | NEW SUBSTITUTED PIPERIDINOGUANIDINES, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOUCHARA S.A. (FR) | 1990-08-08 | — | — | EP | claimed |
| US-20150266864-A1 | HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN | CRISTÁLIA PRODUTOS QUÍMICOS FARMACÊUTICOS LTDA (BR) | 2015-09-24 | — | — | US | disclosed |
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |
| EP-0041493-B1 | USE OF GAMMA-PIPERIDINO-BUTYROPHENONES FOR THE PREPARATION OF MEDICAMENTS FOR TREATING DIARRHOEA | AB Ferrosan (SE) | 1987-03-04 | — | — | EP | disclosed |
| US-4344952-A | Method of treating diarrhoea with gamma-piperidino-butyrophenones | AB FERROSAN (SE) | 1982-08-17 | — | — | US | disclosed |
| EP-0041493-A1 | Use of gamma-piperidino-butyrophenones for the preparation of medicaments for treating diarrhoea | AB Ferrosan (SE) | 1981-12-09 | — | — | EP | disclosed |
| US-4148796-A | γ-Piperidinobutyrophenones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-04-10 | — | — | US | disclosed |
| US-4148796-A | γ-Piperidinobutyrophenones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-04-10 | — | — | US | disclosed |
| US-4148796-A | γ-Piperidinobutyrophenones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-04-10 | — | — | US | disclosed |
| US-4100291-A | HYPOTENSIVE | ROUSSEL UCLAF (FR) | 1978-07-11 | — | — | US | disclosed |
| US-4070473-A | CNS DEPRESSANTS | AB FERROSAN (SW) | 1978-01-24 | — | — | US | disclosed |
| US-4054570-A | NEUROLEPTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1977-10-18 | — | — | US | disclosed |
| US-4021563-A | Method of treating cardiac arrhythmia with γ-piperidino-butyrophenones | NOVO NORDISK A/S | 1977-05-03 | — | — | US | disclosed |
| US-4012514-A | Aryl ketones and production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-03-15 | — | — | US | disclosed |
| US-3992546-A | 4-Piperidinobutyrophenones as neuroleptics | CIBA-GEIGY CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |
| US-3907812-A | Butyrophenone derivatives | SUMITOMO CHEMICAL CO (JP) | 1975-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266864-A1 | HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN | TRPV1, AP1G1, INA | ALDH1A1 306/4885KMT2A 2470/4885GFER 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.