Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | GFER | P55789 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182996 | 0.98 | ALDH1A1 (0.76) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| SCHEMBL7645836 | 0.95 | ALDH1A1 (0.81) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| SCHEMBL10603564 | 0.95 | ALDH1A1 (0.81) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL10606849 | 0.94 | ALDH1A1 (0.82) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| SCHEMBL10107784 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERL3MBTL1MAPT | |
| SCHEMBL5356971 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERL3MBTL1MAPT | |
| SCHEMBL8525343 | 0.88 | ALDH1A1 (0.70) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| Fumaric Acid SCHEMBL10619017 | 0.88 | ALDH1A1 (0.70) | ALDH1A1KMT2AGFERL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL10675086 | 0.87 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERMAPTLMNA | |
| Hydrochloric Acid SCHEMBL29354698 | 0.87 | ALDH1A1 (1.00) | ALDH1A1KMT2AGFERMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898909-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-10-19 | — | — | EP | disclosed |
| EP-1898909-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-10-19 | — | — | EP | disclosed |
| EP-2099758-B1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-09 | — | — | EP | disclosed |
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| CN-101252927-B | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV | 2014-01-01 | — | — | CN | disclosed |
| US-8415475-B2 | Antibacterial quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-04-09 | — | — | US | disclosed |
| US-20130030016-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ANDRIES KOENRAAD JOZEF LODEWIJK (BE) | 2013-01-31 | — | — | US | disclosed |
| US-20130030016-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ANDRIES KOENRAAD JOZEF LODEWIJK (BE) | 2013-01-31 | — | — | US | disclosed |
| US-20130030016-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ANDRIES KOENRAAD JOZEF LODEWIJK (BE) | 2013-01-31 | — | — | US | disclosed |
| EP-1898914-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-15 | — | — | EP | disclosed |
| US-20100197727-A1 | Quinoline Derivatives as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-05 | — | — | US | disclosed |
| US-20100197727-A1 | Quinoline Derivatives as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-05 | — | — | US | disclosed |
| US-20100197727-A1 | Quinoline Derivatives as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-05 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048566-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N,V, (BE) | 2010-02-25 | — | — | US | disclosed |
| WO-2007000435-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007000434-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, HRH1, HRH2 | ALDH1A1 776/4885KMT2A 2586/4885GFER 293/4885 |
| US-20130030016-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, NDUFB10, NDUFB7 | ALDH1A1 2495/4885KMT2A 4093/4885GFER 896/4885 |
| US-20100048566-A1 | ANTIBACTERIAL QUINOLINE DERIVATIVES | NQO2, NDUFB7, NDUFB5 | ALDH1A1 2340/4885KMT2A 3901/4885GFER 1367/4885 |
| US-20100197727-A1 | Quinoline Derivatives as Antibacterial Agents | QTRT1, QSOX1, NQO2 | ALDH1A1 1387/4885KMT2A 3363/4885GFER 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.