Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11461527 | 0.84 | PLA2G4B (0.50) | L3MBTL1ALDH1A1TSHR | |
| SCHEMBL862846 | 0.84 | HSD17B3 (0.58) | ALDH1A1SLC6A2ESR1CHRM1TSHR | |
| SCHEMBL7650212 | 0.82 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1SLC6A2ESR1CHRM1 | |
| SCHEMBL2126591 | 0.81 | LMNA (0.56) | L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL8218440 | 0.81 | L3MBTL1 (0.68) | L3MBTL1ALDH1A1TSHR | |
| SCHEMBL7646419 | 0.81 | HDAC3 (0.56) | L3MBTL1ALDH1A1 | |
| SCHEMBL7646664 | 0.79 | HAO1 (0.46) | L3MBTL1ALDH1A1SLC6A2ESR1CHRM1 | |
| SCHEMBL6963661 | 0.77 | SMN1; SMN2 (0.54) | L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL6040897 | 0.77 | TPMT (0.46) | TPMTCA1CA2PDPK1 | |
| SCHEMBL11444536 | 0.77 | GSK3B (0.54) | L3MBTL1ALDH1A1TSHRTDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |