SCHEMBL7647403

SCHEMBL7647403

CC(C)N(CCN1CCc2ccc(N)cc21)C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
LMNA P02545 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
PTK2B Q14289 1/20 0.44
ESR2 Q92731 1/20 0.44
HTR2A P28223 6/20 0.44
HTR2C P28335 6/20 0.44
HTR2B P41595 6/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
NFKB1 P19838 1/20 0.44
HIF1A Q16665 1/20 0.44
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
CDK4 P11802 1/20 0.38
ALOX15 P16050 1/20 0.38
CCND1 P24385 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428784 0.92 BRD4 (0.40) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL4200884 0.84 ALDH1A1 (0.63) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL14827765 0.81 ALDH1A1 (0.44) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL14827747 0.79 ALDH1A1 (0.47) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL12333943 0.76 ALDH1A1 (0.50) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL2674785 0.76 ALDH1A1 (0.52) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL2267570 0.76 HTR2A (0.45) ALDH1A1LMNAKDM4EMAPTHTR2A
SCHEMBL12333947 0.75 LMNA (0.45) ALDH1A1LMNAKDM4EMAPTPTK2B
SCHEMBL12334040 0.75 ALDH1A1 (0.41) ALDH1A1LMNAKDM4EMAPTPTK2B
Hydrochloric Acid SCHEMBL20136159 0.75 ALDH1A1 (0.51) ALDH1A1LMNAKDM4EMAPTPTK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100495-A4 PROPENAMIDES AS CCR5 MODULATORS SMITHKLINE BEECHAM CORP (US) 2002-09-25 EP disclosed
EP-1100495-A1 PROPENAMIDES AS CCR5 MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-23 EP disclosed
WO-2000006153-A1 PROPENAMIDES AS CCR5 MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed