Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CPA3 | P15088 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380508 | 0.87 | CPA3 (0.46) | FFAR1FOLH1ALDH1A1CPA3KDM4E | |
| SCHEMBL11488435 | 0.79 | FFAR1 (0.44) | KMT2AFFAR1L3MBTL1FOLH1ALDH1A1 | |
| SCHEMBL3384127 | 0.75 | CYP1A2 (0.39) | FOLH1 | |
| SCHEMBL7654496 | 0.74 | EPOR (0.46) | KMT2AFFAR1PTGFRMEN1 | |
| SCHEMBL3380552 | 0.73 | HDAC1 (0.49) | FFAR1FOLH1CPA3MAPK1 | |
| SCHEMBL3382538 | 0.72 | CYP1A2 (0.37) | FFAR1FOLH1HSD17B10 | |
| SCHEMBL3383403 | 0.71 | AKR1B1 (0.38) | KMT2AFFAR1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL7645575 | 0.69 | CYP1A2 (0.55) | FFAR1CYP2D6 | |
| SCHEMBL7644621 | 0.69 | FFAR1 (0.42) | KMT2AFFAR1ALDH1A1CPA3 | |
| SCHEMBL28600697 | 0.69 | TAS2R14 (0.44) | ALDH1A1POLBCYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372726-B1 | ADMINISTERING CARBOXYALKYL PHOSPHONATE, PHOSPHORAMIDATE, OR PHOSPHINE OXIDE DERIVATIVE AS ANTITUMOR AGENT TO TREAT CANCER OF PROSTATE GLAND | GUILFORD PHARMACEUTICALS INC. | 2002-04-16 | — | — | US | disclosed |