Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 9/20 | 0.50 |
| ▸ | BAX | Q07812 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609683 | 0.82 | BAX (0.67) | CARM1BAXMAPTTP53CYP3A4 | |
| SCHEMBL7652515 | 0.79 | MAPT (0.53) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL7649914 | 0.79 | IGF1R (0.47) | MAPTTP53CYP3A4MAPK1MEN1 | |
| SCHEMBL7648451 | 0.77 | TP53 (0.42) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7653470 | 0.77 | LMNA (0.47) | MAPTCYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL7648593 | 0.76 | GPR183 (0.44) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL157776 | 0.76 | BAX (0.51) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL7647940 | 0.75 | SMN1; SMN2 (0.40) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL7651244 | 0.75 | SIGMAR1 (0.44) | BAXMAPTTP53SMN1; SMN2 | |
| SCHEMBL7646726 | 0.75 | LMNA (0.37) | BAXMAPTTP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | claimed |