Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | BAX | Q07812 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606837 | 0.80 | BAX (0.66) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL7649914 | 0.80 | IGF1R (0.47) | MAPTTP53MAPK1CYP3A4KMT2A | |
| SCHEMBL7647658 | 0.79 | CARM1 (0.50) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL7647940 | 0.78 | SMN1; SMN2 (0.40) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL7648451 | 0.78 | TP53 (0.42) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7648593 | 0.77 | GPR183 (0.44) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL157776 | 0.77 | BAX (0.51) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL7646726 | 0.76 | LMNA (0.37) | MAPTBAXTP53MAPK1CYP3A4 | |
| SCHEMBL7651244 | 0.76 | SIGMAR1 (0.44) | MAPTBAXTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL15571308 | 0.75 | DNM1 (0.46) | MAPTBAXTP53MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |