Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651643 | 0.76 | BCHE (0.51) | MEN1KMT2AHTT | |
| SCHEMBL7648546 | 0.76 | ALDH1A1 (0.51) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| SCHEMBL7651942 | 0.76 | ALDH1A1 (0.53) | KDM4EALDH1A1GAAHPGDPARP1 | |
| Hydrochloric Acid SCHEMBL7656315 | 0.75 | BCHE (0.50) | MEN1KMT2AHTT | |
| SCHEMBL7656663 | 0.73 | HDAC1 (0.46) | HDAC1HDAC8HDAC6ALDH1A1MAPT | |
| SCHEMBL7650175 | 0.71 | PARP1 (0.50) | ALDH1A1HPGDPARP1MAPTSMN1; SMN2 | |
| SCHEMBL7649548 | 0.69 | HDAC1 (0.46) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| SCHEMBL12794035 | 0.68 | MEN1 (0.48) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL30704400 | 0.68 | LMNA (0.68) | ALDH1A1HPGDMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7650329 | 0.68 | HDAC1 (0.42) | HDAC1HDAC8HDAC6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |