Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGFR | P43088 | 1/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048450 | 0.85 | AKR1B1 (0.42) | ALDH1A1CPA3KDM4ENAALAD2CYP2D6 | |
| SCHEMBL7642964 | 0.82 | CPA3 (0.55) | CPA3NAALAD2KEAP1CYP1A2 | |
| SCHEMBL5051226 | 0.79 | CXCL8 (0.37) | ALDH1A1MEN1KMT2AFOLH1CPA3 | |
| SCHEMBL7650843 | 0.78 | FOLH1 (0.44) | KMT2AFOLH1PPARGPPARACPA3 | |
| SCHEMBL7036604 | 0.78 | KEAP1 (0.47) | CPA3NAALAD2KEAP1CYP2C19MAPK1 | |
| SCHEMBL7855611 | 0.76 | FOLH1 (0.40) | FOLH1CPA3CYP1A2 | |
| SCHEMBL20508880 | 0.75 | PTPRA (0.50) | ALDH1A1CPA3CYP2D6CYP1A2TSHR | |
| SCHEMBL5053327 | 0.73 | CPA3 (0.38) | ALDH1A1MEN1KMT2ACPA3KDM4E | |
| SCHEMBL5052977 | 0.73 | GAA (0.41) | ALDH1A1MEN1KMT2AFOLH1CPA3 | |
| SCHEMBL7644621 | 0.73 | FFAR1 (0.42) | ALDH1A1KMT2APPARGPPARACPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |