Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692039 | 0.74 | PPARG (0.53) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL9402468 | 0.73 | ACHE (0.44) | ACHEPPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL5411252 | 0.72 | AGTR1 (0.43) | ACHEPPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL4253889 | 0.70 | HSD17B10 (0.58) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL9402217 | 0.69 | POLB (0.66) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL1894100 | 0.69 | AGTR1 (0.68) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL9682387 | 0.69 | AGTR1 (0.43) | ACHEPPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL6954317 | 0.69 | HSD17B10 (0.60) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL10718048 | 0.69 | HSD17B10 (0.60) | ACHEPPARGAGTR1AGTR2 | |
| SCHEMBL6954649 | 0.69 | HSD17B10 (0.60) | ACHEPPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |