Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 10/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653470 | 0.88 | LMNA (0.47) | LMNANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL7649479 | 0.83 | SIGMAR1 (0.47) | LMNAKDM4EMAPTALDH1A1HIF1A | |
| SCHEMBL607613 | 0.80 | RAD52 (0.62) | LMNANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL607612 | 0.80 | RAD52 (0.62) | LMNANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL7653005 | 0.76 | TSHR (0.40) | LMNAKDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL14024640 | 0.72 | LMNA (0.70) | LMNANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL7648753 | 0.72 | ALDH1A1 (0.61) | LMNANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL7649914 | 0.71 | IGF1R (0.47) | LMNAKDM4EMAPTALDH1A1POLB | |
| SCHEMBL7648599 | 0.71 | CHRM2 (0.42) | KDM4EALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL11403897 | 0.70 | LMNA (0.63) | LMNANPSR1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | claimed |