SCHEMBL7649802

SCHEMBL7649802

ClC(Cl)(c1ccccc1)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.54
TSHR P16473 2/20 0.50
CYP1A2 P05177 2/20 0.48
ALDH1A1 P00352 3/20 0.47
CYP2C9 P11712 1/20 0.46
PTPN5 P54829 1/20 0.43
TAAR1 Q96RJ0 2/20 0.42
MAPK1 P28482 1/20 0.42
CYP3A4 P08684 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MMP3 P08254 1/20 0.42
BCL2L1 Q07817 1/20 0.42
AKT1 P31749 1/20 0.38
AKT2 P31751 1/20 0.38
KCNN4 O15554 1/20 0.38
PTPN1 P18031 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
MGLL Q99685 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11670749 0.89 TSHR (0.61) KIF11TSHRCYP1A2ALDH1A1TAAR1
SCHEMBL151981 0.86 TSHR (0.65) TSHRCYP1A2ALDH1A1CYP2C9TAAR1
Ammonia Solution, Strong SCHEMBL31241190 0.83 TSHR (0.61) TSHRCYP1A2ALDH1A1CYP2C9TAAR1
Hydrochloric Acid SCHEMBL15864874 0.83 TSHR (0.61) TSHRCYP1A2ALDH1A1CYP2C9TAAR1
SCHEMBL28193891 0.83 TSHR (0.61) TSHRCYP1A2ALDH1A1CYP2C9TAAR1
SCHEMBL10661427 0.81 TSHR (0.68) KIF11TSHRCYP1A2ALDH1A1CYP2C9
SCHEMBL12305490 0.81 TSHR (0.52) KIF11TSHRCYP1A2ALDH1A1CYP2C9
SCHEMBL27398777 0.80 PTPN1 (0.50) KIF11TSHRCYP1A2ALDH1A1PTPN5
SCHEMBL7646185 0.79 TSHR (0.50) KIF11TSHRCYP1A2MAPK1
SCHEMBL20806535 0.78 KIF11 (0.59) KIF11TSHRCYP1A2ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001049642-A1 METHOD FOR PRODUCING DIARYLKETONES AND ACID HALIDES TESSENDERLO CHEMIE N.V. (BE) 2001-07-12 WO claimed
WO-2024149694-A1 NITROGENOUS HETEROCYCLES FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-07-18 WO disclosed
WO-2024094592-A2 NITROGENOUS HETEROCYCLES FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-05-10 WO disclosed
WO-2002042246-A1 METHOD FOR THE PREPARATION OF DICHLORODIARYLMETHANES TESSENDERLO CHEMIE N.V. (BE) 2002-05-30 WO disclosed
WO-2001049642-A1 METHOD FOR PRODUCING DIARYLKETONES AND ACID HALIDES TESSENDERLO CHEMIE N.V. (BE) 2001-07-12 WO disclosed
US-3985766-A ANTIMYCOTICS BAYER AKTIENGESELLSCHAFT (DT) 1976-10-12 US disclosed