Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649768 | 0.87 | TNF (0.70) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7654430 | 0.87 | TNF (0.70) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7650022 | 0.79 | TNF (0.73) | TNFCNR2ALDH1A1L3MBTL1CTNNB1 | |
| SCHEMBL7656518 | 0.77 | TNF (0.67) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7655134 | 0.76 | TNF (0.51) | TNFCNR2ALDH1A1L3MBTL1HTT | |
| SCHEMBL7650027 | 0.75 | TNF (0.68) | TNFCNR2ALDH1A1L3MBTL1CTNNB1 | |
| SCHEMBL7651184 | 0.75 | ALDH1A1 (0.50) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7648268 | 0.75 | TNF (0.53) | TNFLMNA | |
| SCHEMBL7654850 | 0.75 | ALDH1A1 (0.50) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7164129 | 0.74 | TNF (1.00) | TNFALDH1A1CTNNB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |