SCHEMBL7650197

SCHEMBL7650197

O=C(CCCF)Nc1cc[c]cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 12/20 0.46
HDAC6 Q9UBN7 12/20 0.46
HDAC3 O15379 11/20 0.46
HDAC2 Q92769 11/20 0.46
CYP3A4 P08684 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
HDAC11 Q96DB2 10/20 0.45
HDAC8 Q9BY41 10/20 0.45
HDAC4 P56524 9/20 0.45
HDAC7 Q8WUI4 9/20 0.45
HDAC9 Q9UKV0 9/20 0.45
HDAC5 Q9UQL6 9/20 0.45
HDAC10 Q969S8 9/20 0.45
NCOR1 O75376 2/20 0.45
NCOR2 Q9Y618 2/20 0.45
KDM4E B2RXH2 1/20 0.45
BRD4 O60885 1/20 0.45
NR1I2 O75469 1/20 0.45
EGFR P00533 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7649858 0.95 HDAC1 (0.49) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL7649864 0.91 TP53 (0.44) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL2184132 0.86 LTA4H (0.51) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL7646575 0.82 CYP3A4 (0.46) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL7652886 0.82 CYP3A4 (0.46) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL6290640 0.82 ALDH1A1 (0.65) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL7648464 0.82 ALDH1A1 (0.47) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL4133285 0.82 ALDH1A1 (0.58) CYP1A2CYP2D6KDM4EALDH1A1
SCHEMBL2181711 0.81 TERT (0.51) HDAC1HDAC6HDAC3HDAC2CYP3A4
SCHEMBL1353608 0.81 TP53 (0.43) HDAC1HDAC6HDAC3HDAC2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002536440-A 2002-10-29 JP claimed
EP-1155007-A2 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES G.D. Searle LLC (US) 2001-11-21 EP claimed
WO-2000047568-A2 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES G.D. SEARLE LLC (US) 2000-08-17 WO claimed
EP-1155007-A2 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES G.D. Searle LLC (US) 2001-11-21 EP disclosed
WO-2000047568-A2 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES G.D. SEARLE LLC (US) 2000-08-17 WO disclosed