Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.61 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.58 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KLK7 | P49862 | 1/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648946 | 1.00 | PREP (0.61) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7648948 | 1.00 | PREP (0.61) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL630241 | 0.99 | PREP (0.62) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL630208 | 0.99 | PREP (0.62) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL82714 | 0.99 | PREP (0.62) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29077433 | 0.97 | PREP (0.61) | PREPFKBP1ACTRB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL29553 | 0.94 | PREP (0.67) | PREPCTRB1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL205223 | 0.94 | PREP (0.67) | PREPCTRB1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL29658848 | 0.94 | PREP (0.67) | PREPCTRB1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL475715 | 0.94 | PREP (0.67) | PREPCTRB1SMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479480-B1 | 1H-INDOLE DERIVATIVES BEARING AN OPTIONALLY SUBSTITUTED PHENYL MOIETY AT THE 2-POSITION OF THE INDOLE RING SYSTEM AND A METHYLENE-LINKED HETEROCYCLIC MOIETY AT THE 3-POSITION OF THE INDOLE RING SYSTEM; SCHIZOPHRENIA TREATMENT | MERCK SHARP & DOHME LTD. (GB) | 2002-11-12 | — | — | US | disclosed |
| WO-2000005229-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |