Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657327 | 0.84 | POLB (0.65) | POLBSMN1; SMN2MEN1KMT2AS1PR3 | |
| SCHEMBL7651627 | 0.79 | POLB (0.76) | POLBRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL7657652 | 0.79 | POLB (0.76) | POLBSMN1; SMN2MEN1KMT2AS1PR3 | |
| SCHEMBL4576597 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDMAPTOPRD1L3MBTL1 | |
| SCHEMBL7655911 | 0.78 | SMN1; SMN2 (0.66) | POLBRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL1383257 | 0.77 | POLB (1.00) | POLBSMN1; SMN2MEN1KMT2AS1PR3 | |
| SCHEMBL4576604 | 0.76 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTOPRD1L3MBTL1 | |
| SCHEMBL1593502 | 0.76 | ALDH1A1 (0.76) | POLBRAB9ASMN1; SMN2NPC1PKM | |
| SCHEMBL7521548 | 0.75 | RAB9A (0.46) | RAB9ASMN1; SMN2NPC1PKMCDK5 | |
| SCHEMBL673385 | 0.75 | HDAC1 (0.69) | POLBSMN1; SMN2MEN1KMT2AS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |