Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657652 | 0.86 | POLB (0.76) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL1383257 | 0.84 | POLB (1.00) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL7657327 | 0.83 | POLB (0.65) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL673385 | 0.82 | HDAC1 (0.69) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL23715874 | 0.79 | POLB (0.76) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL7655911 | 0.79 | SMN1; SMN2 (0.66) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL7650752 | 0.79 | POLB (0.60) | POLBKMT2AMEN1S1PR3SMN1; SMN2 | |
| SCHEMBL27481438 | 0.77 | MAPT (0.55) | POLBKMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL14254805 | 0.77 | ALDH1A1 (0.66) | POLBKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL1719786 | 0.77 | RAB9A (1.00) | POLBKMT2AMEN1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1033366-A2 | Amide derivatives useful as Neuropeptide Y (NPY) antagonists | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |