Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649539 | 0.84 | RAD52 (0.46) | MEN1KMT2A | |
| SCHEMBL7647642 | 0.81 | BAX (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL7648011 | 0.81 | MEN1 (0.43) | MEN1KMT2AMAPTSIGMAR1 | |
| SCHEMBL7649884 | 0.80 | TSPO (0.39) | MEN1KMT2AHTR7 | |
| SCHEMBL7653388 | 0.78 | RAD52 (0.39) | MEN1KMT2A | |
| SCHEMBL7649923 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AMAPTLMNA | |
| SCHEMBL1149958 | 0.76 | MEN1 (1.00) | MEN1KMT2AMAPTLMNAPOLB | |
| SCHEMBL7646727 | 0.76 | HTR1A (0.40) | MEN1KMT2AMAPTLMNAHTR7 | |
| SCHEMBL608452 | 0.74 | RAD52 (0.69) | MEN1KMT2AMAPTLMNAPOLB | |
| SCHEMBL157776 | 0.74 | BAX (0.51) | MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | claimed |