Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269951 | 0.78 | SLC6A2 (0.41) | F2ALDH1A1HSD17B10TDP1L3MBTL1 | |
| SCHEMBL11039440 | 0.77 | LMNA (0.53) | F2ALDH1A1HSD17B10TDP1RECQL | |
| SCHEMBL11582477 | 0.76 | CA12 (0.52) | ALDH1A1TDP1RECQLL3MBTL1AKR1C3 | |
| SCHEMBL27612537 | 0.75 | TDP1 (0.53) | F2ALDH1A1TDP1RECQLAKR1C3 | |
| SCHEMBL1202976 | 0.74 | F2 (0.39) | F2ALDH1A1HSD17B10TDP1AKR1C3 | |
| SCHEMBL28004805 | 0.72 | ALDH1A1 (0.54) | ALDH1A1HSD17B10GAACA12CA1 | |
| SCHEMBL27734602 | 0.72 | AKR1C3 (0.52) | F2TDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL11117708 | 0.72 | ESR1 (0.52) | HSD17B10TDP1L3MBTL1PTGS1GAA | |
| SCHEMBL2391876 | 0.71 | HSD17B2 (0.57) | ALDH1A1GAAKDM4ELMNACYP3A4 | |
| SCHEMBL27747165 | 0.71 | CPB2 (0.47) | F2ALDH1A1TDP1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |