Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 5/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655267 | 0.86 | MAPT (0.69) | MAPTTHRBRXFP1MEN1KMT2A | |
| SCHEMBL4171480 | 0.84 | MAPT (0.56) | MAPTTHRBPDE1BKDM4EUBE2N | |
| SCHEMBL7648583 | 0.79 | HDAC1 (0.59) | MAPTTHRBRXFP1MEN1KMT2A | |
| SCHEMBL7651126 | 0.77 | MAPT (0.72) | MAPTTHRBRXFP1MEN1KMT2A | |
| SCHEMBL7648500 | 0.76 | HDAC1 (0.45) | MAPTTHRBPDE1BKDM4EMEN1 | |
| SCHEMBL7648333 | 0.76 | HDAC6 (0.48) | MAPTTHRBRXFP1MEN1KMT2A | |
| SCHEMBL7654277 | 0.76 | CCR2 (0.45) | MAPTTHRBRXFP1MEN1TSHR | |
| SCHEMBL4174608 | 0.74 | MAPT (0.51) | MAPTTHRBUBE2NRXFP1ADORA3 | |
| SCHEMBL7650053 | 0.73 | HDAC1 (0.52) | MAPTKDM4ERXFP1 | |
| SCHEMBL7648551 | 0.73 | HDAC1 (0.51) | MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |