Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | AGER | Q15109 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427850 | 0.75 | CYP11B1 (0.54) | PDE10ANOTUMALDH1A1PDE3BPDE3A | |
| SCHEMBL4428136 | 0.74 | PDE10A (0.61) | PDE10AALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL25061854 | 0.72 | SORD (0.47) | PDE10AALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL21434928 | 0.72 | GRM5 (0.41) | PDE10ANOTUMGRM5GRM1L3MBTL1 | |
| SCHEMBL4433578 | 0.70 | NOTUM (0.56) | PDE10ANOTUML3MBTL1HPGDKDM4E | |
| SCHEMBL4427538 | 0.69 | PDE10A (0.41) | PDE10ANOTUML3MBTL1MAPTPDE3B | |
| SCHEMBL4422256 | 0.69 | NCOA3 (0.56) | PDE10ANOTUMALDH1A1L3MBTL1MAPT | |
| SCHEMBL1506695 | 0.68 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPTHPGDKDM4E | |
| SCHEMBL4433834 | 0.68 | CPB2 (0.50) | PDE10ANOTUMALDH1A1L3MBTL1MAPT | |
| SCHEMBL4425401 | 0.67 | PDE3B (0.40) | PDE10ANOTUMGRM5GRM1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020151715-A1 | Imidazole derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2002-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151715-A1 | Imidazole derivatives | GRIN2B, GRIN1, GRIN2A | PDE10A 1675/4885NOTUM 4107/4885GRM5 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.