Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954242 | 0.97 | AR (0.47) | PDE5APDE1APDE1BPDE1CAR | |
| SCHEMBL27529570 | 0.87 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CAR | |
| SCHEMBL4696500 | 0.80 | ALDH1A1 (0.55) | ARIMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL21823418 | 0.77 | FPR2 (0.46) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL7653423 | 0.74 | KMT2A (0.43) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL23880593 | 0.73 | ALDH1A1 (0.52) | ARIMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL4673334 | 0.73 | NPC1 (0.47) | PDE5APDE1APDE1BPDE1CAR | |
| SCHEMBL21918751 | 0.72 | FPR2 (0.45) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL6876868 | 0.71 | PDE4A (0.44) | PDE4BALDH1A1PDE4APDE4DPDE4C | |
| SCHEMBL4940189 | 0.71 | PDE4A (0.55) | PDE5APDE1APDE1BPDE1CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |