Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 3/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823828 | 0.81 | CES2 (0.43) | SMN1; SMN2TDP1ALDH1A1HTTTSHR | |
| SCHEMBL1690169 | 0.77 | TDP1 (0.40) | SMN1; SMN2TDP1CES2CES1POLB | |
| SCHEMBL9889145 | 0.76 | CA1 (0.33) | SMN1; SMN2TDP1CES2CES1CA1 | |
| SCHEMBL24436952 | 0.74 | HSD17B1 (0.44) | — | |
| SCHEMBL10581003 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2TDP1ALDH1A1HTTTSHR | |
| SCHEMBL155657 | 0.74 | KMT2A (0.41) | SMN1; SMN2ALDH1A1HTTTSHRCES2 | |
| SCHEMBL20544022 | 0.73 | SMN1; SMN2 (0.37) | SMN1; SMN2TDP1ALDH1A1HTTTSHR | |
| SCHEMBL22342670 | 0.72 | CES2 (0.38) | SMN1; SMN2ALDH1A1TSHRCES2CES1 | |
| SCHEMBL6561685 | 0.71 | TSHR (0.46) | SMN1; SMN2ALDH1A1HTTTSHRCES2 | |
| SCHEMBL29467941 | 0.71 | CES2 (0.68) | SMN1; SMN2TSHRCES2CES1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002072025-A2 | IMPROVING POSTSYNAPTIC RESPONSE BY A COMBINATION OF 4-MINOPYRIDINE AND AGONIST | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) | 2002-09-19 | — | — | WO | disclosed |