Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663741 | 0.94 | HRH1 (0.69) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL7654432 | 0.90 | HRH1 (0.61) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL7657109 | 0.89 | ADRA1A (0.71) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL7654453 | 0.89 | HRH1 (0.60) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL11718665 | 0.85 | HRH1 (0.65) | HRH1HRH3SIGMAR1 | |
| SCHEMBL7653700 | 0.83 | OPRM1 (0.55) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL7665373 | 0.82 | ADRA1A (0.61) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL7658029 | 0.81 | ADRA1A (0.60) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL7681283 | 0.80 | HRH1 (0.57) | HRH1HRH3ADRA1AADRA1DADRA1B | |
| SCHEMBL11720455 | 0.80 | SIGMAR1 (0.88) | HRH1HRH3ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436962-B1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS; RELIEF FROM BENIGN PROSTATIC HYPERPLASIA BY LESS HINDERED URINE FLOW BY RELAXING SMOOTH MUSCLE TISSUE; WITH A TESTOSTERONE 5-ALPHA REDUCTASE INHIBITOR, FINASTERIDE; ACUTE AND CHRONIC RELIEF | MERCK & CO., INC. | 2002-08-20 | — | — | US | claimed |
| US-6436962-B1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS; RELIEF FROM BENIGN PROSTATIC HYPERPLASIA BY LESS HINDERED URINE FLOW BY RELAXING SMOOTH MUSCLE TISSUE; WITH A TESTOSTERONE 5-ALPHA REDUCTASE INHIBITOR, FINASTERIDE; ACUTE AND CHRONIC RELIEF | MERCK & CO., INC. | 2002-08-20 | — | — | US | disclosed |