Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593502 | 0.88 | ALDH1A1 (0.76) | ALDH1A1NPC1HPGDRAB9AHTT | |
| SCHEMBL1593930 | 0.86 | ALDH1A1 (0.67) | ALDH1A1NPC1HPGDRAB9AHTT | |
| SCHEMBL1594444 | 0.83 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ACYP1A2POLB | |
| SCHEMBL7651771 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HPGDHTTPOLBSMN1; SMN2 | |
| SCHEMBL1593422 | 0.74 | MEN1 (0.74) | ALDH1A1NPC1RAB9AHTTPOLB | |
| SCHEMBL7652121 | 0.73 | POLB (0.60) | ALDH1A1HTTPOLBSCN1ASCN4A | |
| SCHEMBL4176762 | 0.72 | KMT2A (0.62) | ALDH1A1NPC1HPGDRAB9AHTT | |
| SCHEMBL16615503 | 0.70 | CA12 (0.61) | ALDH1A1RAB9AHTTPOLBSMN1; SMN2 | |
| SCHEMBL3570640 | 0.68 | GCK (0.52) | ALDH1A1NPC1HPGDRAB9AHTT | |
| SCHEMBL6699009 | 0.68 | POLB (0.69) | ALDH1A1POLBSCN1ASCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |